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BS Mechanical Engineering

Purdue University 2021 

 

PhD Biomedical Engineering

University of Cincinnati 2025 

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Incoming Postdoctoral Fellow

Tufts University 

Maulee Sheth

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I’m an engineer, researcher, and educator passionate about uncovering how physical forces shape biology. My work brings together mechanobiology, microfluidics, and extracellular vesicle biology. With training in Mechanical and Biomedical Engineering, I specialize in 3D cell culture, tissue engineering, advanced imaging, and EV analysis to investigate disease progression and therapeutic strategies.

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I received my B.S. in Mechanical Engineering from Purdue University in 2021, where I worked with Prof. Cagri Savran. I received my Ph.D. in Biomedical Engineering with Prof. Leyla Esfandiari at the University of Cincinnati in 2025. I am an incoming postdoctoral fellow with Prof. Shelly Peyton at Tufts University. 

Research Interests

I specialize in engineering 3D culture systems to investigate how cells respond to matrix biomechanics, radiation therapy, and phenotypic variability at the single-cell level. A key area of my work examines how mechanical cues shape the secretion and molecular composition of extracellular vesicles.

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My broader interests lie at the intersection of cell mechanics, mechanotransduction, and microfluidics, driven by a commitment to applying engineering solutions to biomedical challenges.

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Publications

Sheth M, Sharma M*, Supasek K*, Lehn M, Takebe T, Takiar V, Wise-Draper T, Chutipongtanate S, Esfandiari L. "Matrix stiffness modulated release of spheroid-derived extracellular vesicles and discovery of Piezo1 cargo", bioRxiv (2025). 10.1101/2025.01.13.632826

*equal contribution

Sheth M, Sharma M, Lehn M, Reza H, Takebe T, Takiar V, Wise-Draper T, Esfandiari L. "Three-Dimensional Matrix Stiffness Modulates Mechanosensitive and Phenotypic Alterations in Oral Squamous Cell Carcinoma Spheroids", APL Bioengineering (2024). 10.1063/5.0210134

Sharma M*, Sheth M*, Poling H, Kuhnell D, Langevin S, Esfandiari L. "Rapid purification and multiparametric characterization of circulating small extracellular vesicles utilizing a label-free lab-on-a-chip device", Scientific Reports (2023). 13:18293 10.1038/s41598-023-45409-4

*equal contribution

Sheth M, Esfandiari L. "Bioelectric dysregulation in cancer initiation, promotion and progression", Frontiers in Oncology (2022). https://doi.org/10.3389/fonc.2022.846917.

Contact
 

Department of Biomedical Engineering, 

College of Engineering and Applied Sciences,

University of Cincinnati

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